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Kevin W. Wellington Nomgqibelo B. P. Nyoka Lyndy J. McGaw 《Drug development research》2019,80(3):386-394
The WHO has stated that antibiotic resistance is escalating to perilously high levels globally and that traditional therapies of antimicrobial drugs are futile against infections caused by resistant microorganisms. Novel antimicrobial drugs are therefore required. We report in this study on the inhibitory activity of the 1,4-naphthoquinone-2,3-bis-sulfides and 1,4-naphthoquinone sulfides against two bacteria and a fungus to determine their antimicrobial properties. The 1,4-naphthoquinone sulfides have potent activity with a minimum inhibitory concentration (MIC) of 7.8 μg/mL against Staphylococcus aureus (Gram +ve), an MIC of 23.4 μg/mL against the fungus, Candida albicans, which was better than that of Amphotericin B (MIC = 31.3 μg/mL), and against Escherichia coli (Gram −ve) an MIC of 31.3 μg/mL was obtained. The 1,4-naphthoquinone had an MIC of 11.7 μg/mL against S. aureus and the 1,4-naphthohydroquinone also had the same activity against E. coli.
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| Hit, Lead & Candidate Discovery |
84.
Prevention Science - The current study tested and identified risk and protective pathways from alcohol expectancies to weekday and weekend consumption to problematic consequences. Adult alcohol... 相似文献
85.
86.
Neil Ryan Johanna Wall Emma J Crosbie Mark Arends Tjalling Bosse Saimah Arif Asma Faruqi Ian Frayling Raji Ganesan Ye L Hock Raymond McMahon Ranjit Manchanda W Glenn McCluggage Pinias Mukonoweshuro Gerhard van Schalkwyk Lucy Side John H Smith Bruce Tanchel D Gareth Evans C Blake Gilks Naveena Singh 《Histopathology》2019,75(6):813-824
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Tryntsje Fokkema Fred Hartgens Bas Kluitenberg Evert Verhagen Frank J.G. Backx Henk van der Worp Sita M.A. Bierma-Zeinstra Bart W Koes Marienke van Middelkoop 《Journal of Science and Medicine in Sport》2019,22(1):106-111
Objectives
To determine the proportion of participants of a running program for novice runners that discontinued running and investigate the main reasons to discontinue and characteristics associated with discontinuation.Design
Prospective cohort study.Methods
The study included 774 participants of Start to Run, a 6-week running program for novice runners. Before the start of the program, participants filled-in a baseline questionnaire to collect information on demographics, physical activity and perceived health. The 26-weeks follow-up questionnaire was used to obtain information on the continuation of running (yes/no) and main reasons for discontinuation. To determine predictors for discontinuation of running, multivariable logistic regression was performed.Results
Within 26 weeks after the start of the 6-week running program, 29.5% of the novice runners (n = 225) had stopped running. The main reason for discontinuation was a running-related injury (n = 108, 48%). Being female (OR 1.74; 95% CI 1.13–2.68), being unsure about the continuation of running after the program (OR 2.06; 95% CI 1.31–3.24) and (almost) no alcohol use (OR 1.62; 95%CI 1.11–2.37) were associated with a higher chance of discontinuation of running. Previous running experience less than one year previously (OR 0.46; 95% CI 0.26–0.83) and a higher score on the RAND-36 subscale physical functioning (OR 0.98; 95% CI 0.96–0.99) were associated with a lower chance of discontinuation.Conclusions
In this group of novice runners, almost one-third stopped running within six months. A running-related injury was the main reason to stop running. Women with a low perceived physical functioning and without running experience were prone to discontinue running. 相似文献88.
M.P. Pereira C. Zeidler T. Nau S. Bobko A.W.M. Evers S. Garcovich M. Gonalo J.A. Halvorsen J. Lambert F.J. Legat T. Leslie M. Metz L. Misery K. Nordlind A. Reich G. Schneider H. Stnder M. Streit J.C. Szepietowski J. Wallengren E. Weisshaar S. Stnder 《Journal of the European Academy of Dermatology and Venereology》2019,33(2):263-266
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